赵梦瑶

生物工程专业：博士生导师

生物学专业：博士生导师

食品科学与工程专业：硕士生导师

生物与医药专业（生物工程领域）：博士生导师/硕士生导师

个人简介

伟德体育，食品科学与工程系系主任，副教授。博士毕业于中国农业大学食品科学与工程专业，博士期间于加拿大渥太华大学食品安全与毒理学系联合培养，于毕业同年入职Bevictor伟德官网。2018年入选上海市“浦江人才”A类计划。

现任上海食品学会青年工作委员会副主任委员、上海市营养学会特医食品专业委员会委员、精准营养与产业专业委员会委员、中国食品学会果蔬加工分会委员。第一届《食品工业科技》杂志青年编委，国际期刊Food Bioengineering 青年编委。

迄今已发表研究论文50余篇，其中以第一作者或通讯作者在Food Chem.，J. Agric. Food Chem., Pharmacological Res., Food Funct., Carbohydrate poly.等SCI期刊发表论文30余篇。主持国家自然科学基金青年科学基金项目，国家重点研发计划重点专项子课题，上海市自然基金面上项目等多个项目或基金。

研究方向：

食品营养与安全

1. 食品功能因子的生理活性评价

2. 低GI食品、特殊医学用途全营养食品创制与开发

主讲课程：

1. 《食品工艺学》，本科专业核心课程（上海市重点课程）

2. 《食品环境学》，本科专业必修课

3. 《分子营养学》，研究生课程

主持或参加的科研项目或基金：

近年来主持多项包括国家自然科学基金青年基金、上海市浦江人才计划、国家重点研发计划子课题、上海市自然基金面上项目等在内的多个省部级项目、人才计划。

1. 主持上海市自然基金面上项目（23ZR1417300），“肠道菌群-肝脏轴”介导功能寡糖调节脂代谢中的分子机制及益生效应；

2. 主持国家重点研发计划子课题（2019YFD0901803-02），水产品智能化加工装备与关键技术;

3. 主持国家自然科学基金青年基金（31801668），食源性有害物丙烯酰胺通过NLRP3炎症小体激活介导神经毒性的机制探索;

4. 主持中国博士后科学基金特别资助（2019T120314），单一聚合度壳寡糖对非酒精性脂肪肝的干预效果及机制研究；

5. 主持上海市浦江人才计划A类（18PJ1401900），NLRP3炎症小体介导的细胞焦亡在食源性有害物丙烯酰胺神经致毒中的机制研究;

6. 主持中国博士后科学基金面上资助（2017M621392），单一聚合度壳寡糖促体内外肝癌细胞凋亡机制研究;

代表性论文：   

1. Liangliang Zhua, Xiangru Feng, Xiaoxuan Lu, Geng Han, Jiaqi Zou,Zhaoyang Dong, Ting Luo, Jiayang Jin,  Mengyao Zhao*,Xiaoguo Ji *, Liming Zhao*(2026). Desulfovibrio-Hydrogen Sulfide Mediates Capsaicin-Induced Oxidative Stress and Gut Inflammation via TXNIP/NLRP3 Pathway. Food Bioengineering. 5, 152–167.

2. Rui Jing,Shanshan Deng, Mengyao Zhao*, and Liming Zhao(2026).  Computer-Aided Functional Oligosaccharide Screening and the Regulatory Role in Lipid Metabolism.Food Bioengineering.5,14–29.

3. Yayu Zhang, XiaoguoJi, KunlinChang, HaoYin, Mengyao Zhao*, and Liming Zhao*(2025). The regulatory effect of chitooligosaccharides on islet inflammation in T2D individuals after islet cell transplantation: the mechanisbehind Candida albicans abundance and macrophage polarization. Gut Microbes. 2442051.

4. Han Ye, Rui Gan, Xiaoguo Ji, Jiayang Jin, Mengyao Zhao*, and Liming Zhao(2025). Chitooligosaccharide ameliorates depression in CUMS mice by regulating gut serotonin metabolism. Food Science and Human Wellness. 9250753.

5. Yuwen Liu^#, Ran Zhang, Jiaqi Zou, Hao Yin, Mengyao Zhao*, Liming Zhao* (2024). The impact of chitooligosaccharides with a certain degree of polymerization on diabetic nephropathic mice and high glucose-damaged HK-2 cells. Food Science & Nutrition. 12, 4173-4184.

6. Yuan Li, Jiaqi Zou, Hao Yin, Mengyao Zhao*, Liming Zhao*(2024). The Preventative Effect of Chitooligosaccharides against Chronic Alcoholic Liver Disease by Regulating Alcohol Metabolism, Fatty Acid Metabolism, and Intestinal Barrier Damage.Journal of Food Biochemistry. 1323706.

7. Xinye Zhuang^#, Mengyao Zhao^#, Xiaoguo Ji, Sihan Yang, Hao Yin, Liming Zhao*(2023). Chitobiose exhibited a lipid-lowering effect in ob/ob−/− mice via butyric acid enrolled liver–gut crosstalk. Bioresour. Bioprocess. 10, 79.

8. Mengyao Zhao^#, Boya Zhang, Linlin Deng, Liming Zhao* (2023). Acrylamide induces neurotoxicity in zebrafish (Danio rerio) via NLRP3-mediated pyroptosis. The Science of the total environment, 165208.

9. Zhuoyu Li^#, Mengyao Zhao^#, Xiaoguo Ji, Liqiang Fan, Liming Zhao*(2023). Alginate oligosaccharides improve high-fat induced hepatic steatosis via PGC-1α-mediated lipophagy and fatty acid β-oxidation pathway. Journal of Functional Foods. 105825.

10. Mengyao Zhao^#, Boya Zhang, Linlin Deng, Liming Zhao*(2022). Acrylamide Induces Neurotoxicity in SH-SY5Y Cells via NLRP3-mediated Pyroptosis. Molecular Neurobiology. 60: 596-609.

11. 叶晗, 李炎鑫, 赵梦瑶, 等. 热风干燥海带含水量近红外光谱预测模型建立及品质评价[J]. 食品科技, 2022, 47(10): 252-259.

12. Jiangshan You^#, Mengyao Zhao^#, Shumin Chen, Lihua Jiang, Shuhong Gao, Hao Yin* and Liming Zhao* (2022), Effect of chitooligosaccharides with a specifc degree of polymerization on multiple targets in T2DM mice. Bioresour. Bioprocess.9:94.

13. Mengyao Zhao^#, Linlin Deng, Xiaoxuan Lu, Liqiang Fan, Yang Zhu, Liming Zhao*(2022). The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice. Environ Sci Pollut Res Int. 29(27):41151-41167.

14. Shumin Chen, Xiaoguo Ji, Mengyao Zhao, Jiayang Jin, Haiping Zhang*, Liming Zhao* (2022). Construction of chitooligosaccharide-based nanoparticles of pH/redox cascade responsive for co-loading cyclosporin A and AZD9291. Carbohydrate Polymers. 291, 119619.

15. Linlin Deng^#, Mengyao Zhao*, Yanan Cui, Quanming Xia, Lihua Jiang, Hao Yin*, Liming Zhao*(2022). Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells. Drug Chem Toxicol. 45(6):2601-2612.

16. Chunfeng Zhu^#, Mengyao Zhao*, Liqiang Fan, Xuni Cao, Quanming Xia, Jiachun Zhou, Hao Yin, Liming Zhao*(2021). Chitopentaose inhibits hepatocellular carcinoma by inducing mitochondrial mediated apoptosis and suppressing protective autophagy. Bioresour. Bioprocess. 8, 4.

17. Xin Shen, Xinyi Liang, Xiaoguo Ji, Jiangshan You, Xinye Zhuang, Yudong Song, Hao Yin, Mengyao Zhao*, Liming Zhao*(2021). CD36 and DGAT2 facilitate the lipid-lowering effect of chitooligosaccharides via fatty acid intake and triglyceride synthesis signaling. Food Funct. 12(18):8681-8693.

18. Mengyao Zhao, Shumin Chen, Xiaoguo Ji, Xingtong Shen, Jiangshan You, Xinyi Liang, Hao Yin, Liming Zhao* (2021). Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease. Pharmacological Research. 105517.

19. Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin*, Liming Zhao* (2021). Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease. Journal of Functional Foods,77, 104333.

参编专著、教材：

1. Mengyao Zhao*, Boya Zhang, Liming Zhao. Acrylamide and Its Neurotoxicity. Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier monograph, 2025, DOI:10.1016/b978-0-323-95702-1.00324-9.

2. Mengyao Zhao, Zhenwei Yi, Boya Zhang, Shumin Chen, Xinye Zhuang, Hao Yin, Liming Zhao*. Chapter 9-Fatty liver disease: Functional foods offer natural remedies. Functional Foods and Chronic Disease. Elsevier monograph, 2024,115-152.

3. 周家春，刘卫兵，赵梦瑶。《食品工艺教材》，化学工业出版社，2025-12。

4. Mengyao Zhao, Zhenwei Yi, Boya Zhang, Shumin Chen, Xinye Zhuang, Hao Yin, Liming Zhao,Chapter 9-Fatty liver disease: Functional foods offer natural remedies, Editor(s): Michel Aliani, Michael N.A. Eskin,Functional Foods and Chronic Disease, Academic Press,2024,Pages 115-152. ISBN 9780323917476.

5. Mengyao Zhao & Liming Zhao. Biological Activities and Potential Application in Food Industry, Oligosaccharides of Chitin and Chitosan: Bio-manufacture and Applications, Springer Nature, 2019. ISBN 978-981-13-9401-0

6. 赵黎明，赵梦瑶。译《第十五章》，《食品分析（第五版）》（国外优秀食品科学与工程专业教材）;中国轻工业出版社。ISBN 978-7-5184-2138-1。

联系方式：

办公室：发酵工业分离提取技术研发中心103

电话：021-64251881

通讯地址：上海市徐汇区梅陇路130号，200237

邮箱：myzhao@ecust.edu.cn